Seminar – MPFI Seminar
Optical methods for mapping cortical and striatal circuitry with cell-type precision
Primary motor cortex contains a large number of cell types whose specific connectivity is unknown. We hypothesize different cell types are connected in specific ways in the mature circuit, and these connections allow different circuit elements to make specific contributions to the planning, initiation, and control of ongoing movements. We use anatomical and physiological techniques to describe the local and long-range connections, taking advantage of tools to label these cell types in transgenic mice. This talk will focus on the organization of long-range output of two types of L5 pyramidal neurons to basal ganglia.