Seminar – Tri-Institutional Seminar
TIPS with Henry Dunn and Madineh Sarvestani
Laboratory of Dr. Kirill Martemyanov, Scripps Research
Endogenous trans-synaptic modulators of group III mGluRs temper neuropsychiatric manifestations
Trans-synaptic modulation of GPCRs represents an emerging dimension in GPCR pharmacology and synaptic function. We demonstrate prototypical glutamatergic autoreceptors rely on endogenous trans-synaptic modulators to fine-tune mGluR activation, control excitability, and temper neuropsychiatric manifestations.
Laboratory of Dr. David Fitzpatrick, MPFI
Functional specialization in secondary visual areas is a byproduct of visuotopy
Seminal studies of the secondary visual area (V2) of the primate reported the existence of functional specialization for various visual features: Different regions of V2 showed sensitivity to different visual features such as color or
orientation. This evidence was used to support the theory that this area
performs several transformations of visual input in parallel. We studied
functional specialization in V2 of two different species and found functional
specialization similar to the primate. However, we also found that this
specialization is intricately tied to the underlying visuotopy in V2. Our
findings challenge the theory of parallel transformations in favor of a simpler
explanation based on the usual elongated shape of V2 in mammals.