Scientific Publications

Complementary roles of cell-type-specific plasticity in shaping neocortical dynamics for learning action timing

Majumder, S., Hirokawa, K., Yang, Z., Jain, A., Paletzki, R., Gerfen, C. R., Fontolan, L., Romani, S., Yasuda, R., & Inagaki, H. K. (2026). Complementary roles of cell-type-specific plasticity in shaping neocortical dynamics for learning action timing. Nature Communications.
 

Activity-regulated circSamm50 modulates mitochondrial dynamics and spine structural plasticity

Chanda, K., Bapat, O., Wingfield, J. L., Avchalumov, Y., Kazantzis, M., Carter, J. P., Sharma, N., Davis, R., Yuan, J. X.-J., Rangaraju, V., & Puthanveettil, S. V. (2026). Activity-regulated circSamm50 modulates mitochondrial dynamics and spine structural plasticity. Cell Reports, 45(6).  

Synchronous climbing fiber activity enables instructive signaling for cerebellar learning through modulation of disinhibitory circuits.

Park, C., Yang, Z., Nashef, A., Gim, J., Bahn, S., Kim, G. H., Zhang, K., Cathala, L., Hong, S., Im, Y., Lee, S.-H., Lee, K., Kim, M.-S., Arnold, D. B., Lee, K. J., Christie, J. M., & Kim, J. S. (2026). Synchronous climbing fiber activity enables instructive signaling for cerebellar learning through modulation of disinhibitory circuits. Nature Neuroscience.
 

argeting the cGAS-STING pathway mitigates Huntington disease pathogenesis in a knock-in mouse model.

Kesharwani, A., Dagar, S., Zuniga, I., Monet, M. C., Halade, G., Upadhyay, G., Nimrod Ramírez-Jarquín, U., Gisselle Lopez-Huerta, V., Mirza, E., Quan, N., & Subramaniam, S. (2026). Targeting the cGAS-STING pathway mitigates Huntington disease pathogenesis in a knock-in mouse model. Proceedings of the National Academy of Sciences of the United States of America, 123(24), e2535879123.
 

Functional imaging of nine distinct neuronal populations under a miniscope in freely behaving animals.

Phillips, M. L., Urban, N. T., Salemi, T., Dong, Z., & Yasuda, R. (2026). Functional imaging of nine distinct neuronal populations under a miniscope in freely behaving animals. eLife, 15, RP110277.  

Central versus peripheral neural control of a coordinated walking pattern in Drosophila

Sapkal, N., Kumar, D. S., Sunke, S., Mancini, N., Pitchford, J., Murakami, K., & Bidaye, S. S. (2026). Central versus peripheral neural control of a coordinated walking pattern in Drosophila. (p. 2026.04.29.721658). bioRxiv.

 

The sound of neural silence

Tjahjono, N., Wang, Y.-S., & Tian, L. (2026). The sound of neural silence. eLife, 15, e111079.
 

Top-down control of the descending pain modulatory system drives multimodal placebo analgesia

Livrizzi, G., Chang-Weinberg, J., Johnson, D. A., Lubejko, S. T., Liao, J., Kimmey, B. A., Dong, C., Li, Y., Beier, K. T., Corder, G., Tian, L., & Banghart, M. R. (2026). Top-down control of the descending pain modulatory system drives multimodal placebo analgesia. Neuron, 0(0).
 

Membrane-associated Rhes-Slc4a7 complex orchestrates tunneling nanotube formation and mutant Huntingtin spread.

Dagar, S., Fernandez, A., Ramírez-Jarquín, U. N., Lopez-Huerta, V. G., Mirza, E., Mohapatra, C., Zuniga, I., Urban, N. T., Crynen, G., Tsaprailis, G., & Subramaniam, S. (2026). Membrane-associated Rhes-Slc4a7 complex orchestrates tunneling nanotube formation and mutant Huntingtin spread. Science Advances, 12(12), eaea1226.
 

Intellectual disability-causing mutations in KIF11 impair microtubule dynamics and dendritic arborization

Wingfield, J. L., Niese, L., Avchalumov, Y., Liu, X., Grover, R., Nakahata, Y., Raveendra, B. L., Gonzalez-Santiago, A. E., Carter, J. P., Yasuda, R., Yuan, J. X.-J., Diez, S., & Puthanveettil, S. V. (2026). Intellectual disability-causing mutations in KIF11 impair microtubule dynamics and dendritic arborization. Nature Communications, 17(1), 4125.
 

Mitochondrial Ca2+ efflux controls neuronal metabolism and long-term memory across species

Amrapali Vishwanath, A., Comyn, T., Mira, R. G., Brossier, C., Pascual-Caro, C., Faour, M., Boumendil, K., Chintaluri, C., Ramon-Duaso, C., Fan, R., Ghosh, K., Farrants, H., Berwick, J.-P., Sivakumar, R., Lopez-Manzaneda, M., Schreiter, E. R., Preat, T., Vogels, T. P., Rangaraju, V., … de Juan-Sanz, J. (2026). Mitochondrial Ca2+ efflux controls neuronal metabolism and long-term memory across species. Nature Metabolism, 1–22.
 

Time or distance encoding by hippocampal neurons via heterogeneous ramping rates

Heldman, R., Pang, D., Zhao, X., Mensh, B., & Wang, Y. (2025). Time or distance encoding by hippocampal neurons via heterogeneous ramping rates. Nature Communications, 16(1), 11083.
 

Stimulation of Ca2+ channel CaV1.2 activity by dopamine signaling augments spatial working memory.

Man, K. N. M., Rougé, S. L. S., Berumen, R. A., Jacobi, A. A., Weiner, J. C., Naderi, S. Y., Ireton, K. E., Estrada-Tobar, Z. M., Zeng, Z., Martinez, J. M., Xiang, Y. K., Nieves-Cintrón, M., Navedo, M. F., Bartels, P., Horne, M. C., & Hell, J. W. (2025). Stimulation of Ca2+ channel CaV1.2 activity by dopamine signaling augments spatial working memory. Science Signaling, 18(916), eadp7760.
 

Integrator dynamics in the cortico-basal ganglia loop for flexible motor timing.

Yang, Z., Inagaki, M., Gerfen, C. R., Fontolan, L., & Inagaki, H. K. (2025). Integrator dynamics in the cortico-basal ganglia loop for flexible motor timing. Nature, 1–10.
 

The highly localized interaction between Neurofascin-186 and Gliomedin promotes subcellular innervation by the chandelier cell.

Hayano, Y., Ishino, Y., Bhat, M. A., Peles, E., & Taniguchi, H. (2025). The highly localized interaction between Neurofascin-186 and Gliomedin promotes subcellular innervation by the chandelier cell. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, e0464252025.
 

Lack of ADAP1/Centaurin-α1 Ameliorates Cognitive Impairment and Neuropathological Hallmarks in a Mouse Model of Alzheimer’s Disease.

Szatmari, E. M., Moran, C., Cohen, S. J., Bashtovyy, D., Jacob, A., Bunner, W., Phipps, M., Lora, J. C., Stackman, R. W., & Yasuda, R. (2025). Lack of ADAP1/Centaurin-α1 Ameliorates Cognitive Impairment and Neuropathological Hallmarks in a Mouse Model of Alzheimer’s Disease. eNeuro, 12(11).  

Absolute measurement of fast and slow neuronal signals with fluorescence lifetime photometry at high temporal resolution

Lodder, B., Kamath, T., Savenco, E., Röring, B., Siegel, M., Chouinard, J. A., Lee, S. J., Zagoren, C., Rosen, P., Hartman, I., Timmins, J., Adan, R., Tian, L., & Sabatini, B. L. (2025). Absolute measurement of fast and slow neuronal signals with fluorescence lifetime photometry at high temporal resolution. Neuron, 113(21), 3554-3566.e7.
 

Hunger modulates exploration through suppression of dopamine signaling in the tail of the striatum

Kamath, T., Lodder, B., Bilsel, E., Green, I., Dalangin, R., Raghubardayal, M., Wang, W., Capelli, P., Legister, J., Timmins, J., Hulshof, L., Wallace, J. B., Tian, L., Uchida, N., Watabe-Uchida, M., & Sabatini, B. L. (2025). Hunger modulates exploration through suppression of dopamine signaling in the tail of the striatum. Neuron, S0896-6273(25)00697-X.
 

Rab10 inactivation promotes AMPAR trafficking and spine enlargement during long-term potentiation.

Wang, J., Nishiyama, J., Parra-Bueno, P., Okaz, E., Oz, G., Liu, X., Watabe, T., Suponitsky-Kroyter, I., McGraw, T. E., Szatmari, E. M., & Yasuda, R. (2025). Rab10 inactivation promotes AMPAR trafficking and spine enlargement during long-term potentiation. eLife, 13, RP103879.
 

BDNF-driven synaptic plasticity requires autocrine matrix metalloproteinase–9 activity.

Legutko, D., Bijoch, L., Olszak, G., Kuźniewska, B., Kalita, K., Yasuda, R., Kaczmarek, L., & Michaluk, P. (2025). BDNF-driven synaptic plasticity requires autocrine matrix metalloproteinase–9 activity. Science Advances, 11(39), eadx2369.  

Thalamus enables active dendritic coupling of inputs arriving at different cortical layers.

Bast, A., Guest, J. M., Fruengel, R., Narayanan, R. T., de Kock, C. P. J., & Oberlaender, M. (2025). Thalamus enables active dendritic coupling of inputs arriving at different cortical layers. Nature Communications, 16(1), 8327.  

Development of coherent cortical responses reflects increased discriminability of feedforward inputs and their alignment with recurrent circuits.

Lempel, A. A., Trägenap, S., Tepohl, C., Kaschube, M., & Fitzpatrick, D. (2025). Development of coherent cortical responses reflects increased discriminability of feedforward inputs and their alignment with recurrent circuits. Neuron, 113(22), 3834-3845.e8.  

Mitochondria structurally remodel near synapses to fuel the sustained energy demands of plasticity

Shah, M., Ghosh, I., Pishos, L., Villani, V., Pancani, T., Yasuda, R., Sun, C., Kamasawa, N., & Rangaraju, V. (2025). Mitochondria structurally remodel near synapses to fuel the sustained energy demands of plasticity (p. 2025.08.27.672715). bioRxiv.
 

Spectral phasor imaging on a commercial confocal microscope without a spectral detector

Longo, E., Costantino, A., Andreoni, A., Bosco, P., Privitera, A. P., Scalisi, S., Malacrida, L., Gulisano, M., & Lanzanò, L. (2025). Spectral phasor imaging on a commercial confocal microscope without a spectral detector. Scientific Reports, 15(1), 31431.
 

lncRNA ADEPTR loss-of-function elicits sex-specific behavioral and spine deficits

Chanda, K., Carter, J. P., Nishizono, H., Raveendra, B. L., Brantley, A., Grinman, E., Espadas, I., Lozano-Villada, S., Wingfield, J. L., Wagner, G., Peterson, A., Yasuda, R., & Puthanveettil, S. V. (2025). lncRNA ADEPTR loss-of-function elicits sex-specific behavioral and spine deficits. iScience, 28(8), 113070.
 

Avoidance engages dopaminergic punishment in Drosophila

Amin, F., Stone, J. T., König, C., Mancini, N., Murakami, K., Bidaye, S. S., Heim, M.-M., Owald, D., Majumder, U., Kadow, I. C. G., Pierzchlińska, A., Litwin-Kumar, A., Barnstedt, O., & Gerber, B. (2025). Avoidance engages dopaminergic punishment in Drosophila (p. 2025.07.07.663268). bioRxiv.
 

Upregulation of L-type Ca2+ channel Cav1.2 activity by dopamine via proximal D1/5 receptor signaling is important for spatial working memory.

Man KNM#, Ireton KE, Martinez JM, Nieves-Cintron M, Navedo MF, Horne MC, and Hell JW#. Upregulation of L-type Ca2+ channel Cav1.2 activity by dopamine via proximal D1/5 receptor signaling is important for spatial working memory. Under revision at Science Signaling. 

The Growing Importance of Neuroscience-Based Research on Eating Disorders Commentary on Lee and Chi (2025)

Berner, L. A., Stern, S. A., Steinglass, J. E., & Walsh, B. T. (2025). The Growing Importance of Neuroscience-Based Research on Eating Disorders Commentary on Lee and Chi (2025). International Journal of Eating Disorders, 58(10), 1904–1906.  

PTEN in somatostatin neurons regulates fear and anxiety and is required for inhibitory synaptic connectivity within central amygdala

Holford, T. W., Letourneau, K. N., Von-Walter, C., Moncaleano, D., Loomis, C. L., & Bolton, M. M. (2025). PTEN in somatostatin neurons regulates fear and anxiety and is required for inhibitory synaptic connectivity within central amygdala. Frontiers in Cellular Neuroscience, 19.  

Dynorphin modulates reward-seeking actions through a pallido-amygdala cholinergic circuit.

Sun, Q., Liu, M., Guan, W., Xiao, X., Dong, C., Bruchas, M. R., Zweifel, L. S., Li, Y., Tian, L., & Li, B. (2025). Dynorphin modulates reward-seeking actions through a pallido-amygdala cholinergic circuit. Neuron, 113(11), 1823-1840.e8.  

Signaling by Intracellular β2-Adrenergic Receptors Regulates AMPA Receptor Trafficking and Synaptic Plasticity.

Lee B, Xing X, Zeng Z, Estrada-Tobar ZM, Kim K, Ireton KE, Man KNM, Jacobi AA, Berumen RA, Weiner JC, Shen A, Xu B, Wang J, Gasser PJ, Navedo MF, Xiang YK, Diaz E, Chen CY, Horne MC, Hell JW. (2025) Signaling by Intracellular β2-Adrenergic Receptors Regulates AMPA Receptor Trafficking and Synaptic Plasticity. Cell Reports. Accepted. 

Direct interoceptive input to the insular cortex shapes learned feeding behavior

Zhao, Z., Xu, B., Anthony, S., Subramanian, S., Granger, B., Von-Walter, C., Mizrachi, E., Kidd, M., Srigiriraju, A., McKie, I., Li, Z., Bolton, M. M., Berto, S., & Stern, S. A. (2025). Direct interoceptive input to the insular cortex shapes learned feeding behavior (p. 2025.05.13.653896). bioRxiv.  

Presynaptic α2δs specify synaptic gain, not synaptogenesis, in the mammalian brain.

Milanick, W., Li, J., Thomas, C. I., Al-Yaari, M., Guerrero-Given, D., Kamasawa, N., & Young, S. M. (2025). Presynaptic α2δs specify synaptic gain, not synaptogenesis, in the mammalian brain. Neuron, 113(12), 1886-1897.e9.
 

Synapses drive local mitochondrial ATP synthesis to fuel plasticity

Ghosh, I., Fan, R., Shah, M., Bapat, O., & Rangaraju, V. (2025). Synapses drive local mitochondrial ATP synthesis to fuel plasticity (p. 2025.04.09.648032). bioRxiv.
 

Meningeal regulatory T cells inhibit nociception in female mice

Midavaine, É., Moraes, B. C., Benitez, J., Rodriguez, S. R., Braz, J. M., Kochhar, N. P., Eckalbar, W. L., Tian, L., Domingos, A. I., Pintar, J. E., Basbaum, A. I., & Kashem, S. W. (2025). Meningeal regulatory T cells inhibit nociception in female mice. Science (New York, N.Y.), 388(6742), 96–104.
 

Unexpected Retinal Abnormalities in the Cone-Dominant Northern Tree Shrew.

Yu, C. T., Follett, H. M., Summerfelt, P., Allen, K. P., Guillaume, C., Freling, S., & Carroll, J. (2025). Unexpected Retinal Abnormalities in the Cone-Dominant Northern Tree Shrew. Advances in Experimental Medicine and Biology, 1468, 235–239.
 

Changes in neurotensin signalling drive hedonic devaluation in obesity.

Gazit Shimoni, N., Tose, A. J., Seng, C., Jin, Y., Lukacsovich, T., Yang, H., Verharen, J. P. H., Liu, C., Tanios, M., Hu, E., Read, J., Tang, L. W., Lim, B. K., Tian, L., Földy, C., & Lammel, S. (2025). Changes in neurotensin signalling drive hedonic devaluation in obesity. Nature.
 

Neurofibromin deficiency alters the patterning and prioritization of motor behaviors in a state-dependent manner

Suarez, G. O., Kumar, D. S., Brunner, H., Knauss, A., Barrios, J., Emel, J., Teel, J., Botero, V., Broyles, C. N., Stahl, A., Bidaye, S. S., & Tomchik, S. M. (2025). Neurofibromin deficiency alters the patterning and prioritization of motor behaviors in a state-dependent manner. Journal of Neuroscience.  

The developmental emergence of reliable cortical representations

Trägenap, S., Whitney, D. E., Fitzpatrick, D., & Kaschube, M. (2025). The developmental emergence of reliable cortical representations. Nature Neuroscience, 1–12.
 

Eye saccades align optic flow with retinal specializations during object pursuit in freely moving ferrets.

Wallace, D. J., Voit, K.-M., Machado, D. M., Bahadorian, M., Sawinski, J., Greenberg, D. S., Stahr, P., Holmgren, C. D., Bassetto, G., Rosselli, F. B., Koseska, A., Fitzpatrick, D., & Kerr, J. N. D. (2025). Eye saccades align optic flow with retinal specializations during object pursuit in freely moving ferrets. Current Biology, 0(0).
 

An expanded palette of bright and photostable organellar Ca2+ sensors

Moret, A., Farrants, H., Fan, R., Zingg, K. G., Silva, B., Roselli, C., Oertner, T. G., Gee, C. E., Hadjieconomou, D., Rangaraju, V., Schreiter, E. R., & Juan-Sanz, J. de. (2025). An expanded palette of bright and photostable organellar Ca2+ sensors. eLife, 14.

 

Convergent state-control of endogenous opioid analgesia.

Kimmey, B. A., Ejoh, L., Shangloo, L., Wojick, J. A., Chehimi, S. N., McCall, N. M., Oswell, C. S., Mahmood, M., Yang, L., Samineni, V. K., Ramakrishnan, C., Deisseroth, K., Crist, R. C., Reiner, B. C., Tian, L., & Corder, G. (2025). Convergent state-control of endogenous opioid analgesia. bioRxiv: The Preprint Server for Biology, 2025.01.03.631111. 

Thalamic opioids from POMC satiety neurons switch on sugar appetite.

Minère, M., Wilhelms, H., Kuzmanovic, B., Lundh, S., Fusca, D., Claßen, A., Shtiglitz, S., Prilutski, Y., Talpir, I., Tian, L., Kieffer, B., Davis, J., Kloppenburg, P., Tittgemeyer, M., Livneh, Y., & Fenselau, H. (2025). Thalamic opioids from POMC satiety neurons switch on sugar appetite. Science (New York, N.Y.), 387(6735), 750–758.
 

Periodic ER-plasma membrane junctions support long-range Ca2+ signal integration in dendrites

Benedetti, L., Fan, R., Weigel, A. V., Moore, A. S., Houlihan, P. R., Kittisopikul, M., Park, G., Petruncio, A., Hubbard, P. M., Pang, S., Xu, C. S., Hess, H. F., Saalfeld, S., Rangaraju, V., Clapham, D. E., De Camilli, P., Ryan, T. A., & Lippincott-Schwartz, J. (2024). Periodic ER-plasma membrane junctions support long-range Ca2+ signal integration in dendrites. Cell.  

Boosting neuronal activity-driven mitochondrial DNA transcription improves cognition in aged mice.

Li, W., Li, J., Li, J., Wei, C., Laviv, T., Dong, M., Lin, J., Calubag, M., Colgan, L. A., Jin, K., Zhou, B., Shen, Y., Li, H., Cui, Y., Gao, Z., Li, T., Hu, H., Yasuda, R., & Ma, H. (2024). Boosting neuronal activity-driven mitochondrial DNA transcription improves cognition in aged mice. Science, 386(6728), eadp6547.
 

Formation of long-term memory without short-term memory revealed by CaMKII inhibition

Shin, M. E., Parra-Bueno, P., & Yasuda, R. (2024). Formation of long-term memory without short-term memory revealed by CaMKII inhibition. Nature Neuroscience, 1–5.
 

Accelerating neuronal imaging with reduced laser power.

Li Y, Guo S, Mattison B, Hu J, Man K, Yang W. Accelerating neuronal imaging with reduced laser power. (2024) Optics & Photonics News. December issue, 2024. 

Isolation of psychedelic-responsive neurons underlying anxiolytic behavioral states

Muir, J., Lin, S., Aarrestad, I. K., Daniels, H. R., Ma, J., Tian, L., Olson, D. E., & Kim, C. K. (2024). Isolation of psychedelic-responsive neurons underlying anxiolytic behavioral states. Science, 386(6723), 802–810.
 

Dietary protein restriction diminishes sucrose reward and reduces sucrose-evoked mesolimbic dopamine signaling in mice.

Wu, C.-T., Gonzalez Magaña, D., Roshgadol, J., Tian, L., & Ryan, K. K. (2024). Dietary protein restriction diminishes sucrose reward and reduces sucrose-evoked mesolimbic dopamine signaling in mice. Appetite, 203, 107673.
 

Stochastic neuropeptide signals compete to calibrate the rate of satiation.

Zhang, S. X., Kim, A., Madara, J. C., Zhu, P. K., Christenson, L. F., Lutas, A., Kalugin, P. N., Sunkavalli, P. S., Jin, Y., Pal, A., Tian, L., Lowell, B. B., & Andermann, M. L. (2024). Stochastic neuropeptide signals compete to calibrate the rate of satiation. Nature.
 

Dopamine release plateau and outcome signals in dorsal striatum contrast with classic reinforcement learning formulations

Kim, M. J., Gibson, D. J., Hu, D., Yoshida, T., Hueske, E., Matsushima, A., Mahar, A., Schofield, C. J., Sompolpong, P., Tran, K. T., Tian, L., & Graybiel, A. M. (2024). Dopamine release plateau and outcome signals in dorsal striatum contrast with classic reinforcement learning formulations. Nature Communications, 15(1), 8856.
 

Dendritic, delayed, and stochastic CaMKII activation underlies behavioral time scale plasticity in CA1 synapses.

Jain, A., Nakahata, Y., Pancani, T., Watabe, T., Rusina, P., South, K., Adachi, K., Yan, L., Simorowski, N., Furukawa, H., & Yasuda, R. (2024). Dendritic, delayed, stochastic CaMKII activation in behavioural time scale plasticity. Nature, 1–9.
 

A Drosophila computational brain model reveals sensorimotor processing

Shiu, P. K., Sterne, G. R., Spiller, N., Franconville, R., Sandoval, A., Zhou, J., Simha, N., Kang, C. H., Yu, S., Kim, J. S., Dorkenwald, S., Matsliah, A., Schlegel, P., Yu, S., McKellar, C. E., Sterling, A., Costa, M., Eichler, K., Bates, A. S., … Scott, K. (2024). A Drosophila computational brain model reveals sensorimotor processing. Nature, 634(8032), 210–219.
 

Neural circuit mechanisms underlying context-specific halting in Drosophila.

Sapkal, N., Mancini, N., Kumar, D. S., Spiller, N., Murakami, K., Vitelli, G., Bargeron, B., Maier, K., Eichler, K., Jefferis, G. S. X. E., Shiu, P. K., Sterne, G. R., & Bidaye, S. S. (2024). Neural circuit mechanisms underlying context-specific halting in Drosophila. Nature, 634(8032), 191–200.  

α1C S1928 Phosphorylation of CaV1.2 Channel Controls Vascular Reactivity and Blood Pressure.

Flores-Tamez V, Baudel MMA, Hong J, Taylor J, Ren L, Le T, Syed A, Moustafa Y, Lemus-Martinez W, Reddy G, Ramer V, Man KNM, Bartels P, Chen-Izu Y, Chen CY, Simo S, Dickson E, Morotti S, Grandi E, Santana LF, Hell JW, Horne MC, Nieves-Cintron M, Navedo MF. (2024) α1C S1928 Phosphorylation of CaV1.2 Channel Controls Vascular Reactivity and Blood Pressure. J. Am. Heart. Assoc. 13(20):e035375.  

Dopamine-mediated formation of a memory module in the nucleus accumbens for goal-directed navigation.

Jung, K., Krüssel, S., Yoo, S., An, M., Burke, B., Schappaugh, N., Choi, Y., Gu, Z., Blackshaw, S., Costa, R. M., & Kwon, H.-B. (2024). Dopamine-mediated formation of a memory module in the nucleus accumbens for goal-directed navigation. Nature Neuroscience, 1–15. https://doi.org/10.1038/s41593-024-01770-9
 

Disrupting the transmembrane domain interface between PMP22 and MPZ causes peripheral neuropathy

Pashkova, N., Peterson, T. A., Ptak, C. P., Winistorfer, S. C., Guerrero-Given, D., Kamasawa, N., Ahern, C. A., Shy, M. E., & Piper, R. C. (2024). Disrupting the transmembrane domain interface between PMP22 and MPZ causes peripheral neuropathy. iScience, 110989.  

Sub-threshold neuronal activity and the dynamical regime of cerebral cortex

Amsalem, O., Inagaki, H., Yu, J., Svoboda, K., & Darshan, R. (2024). Sub-threshold neuronal activity and the dynamical regime of cerebral cortex. Nature Communications, 15(1), 7958.
 

Homeostatic feeding in hedonic centres

Zhao, Z., & Stern, S. A. (2024). Homeostatic feeding in hedonic centres. Nature Metabolism, 6(8), 1433–1434.  

An activity-regulated transcriptional program directly drives synaptogenesis.

Yee, C., Xiao, Y., Chen, H., Reddy, A. R., Xu, B., Medwig-Kinney, T. N., Zhang, W., Boyle, A. P., Herbst, W. A., Xiang, Y. K., Matus, D. Q., & Shen, K. (2024). An activity-regulated transcriptional program directly drives synaptogenesis. Nature Neuroscience, 27(9), 1695–1707.
 

Resveratrol natural product inspired compound as a potent neuroprotectant against acute oxidative stress.

Simonson, A., Naraine, A., Maki, S., Nugent, K., Lepore, S., & Dawson-Scully, K. (2024). Resveratrol natural product inspired compound as a potent neuroprotectant against acute oxidative stress. microPublication Biology, 2024.
 

High-speed two-photon microscopy with adaptive line-excitation.

Li Y, Guo S, Mattison B, Hu J, Man KNM, Yang W. (2024) High-speed two-photon microscopy with adaptive line-excitation. Optica. 11(8), 1138-1145.  

Unlocking opioid neuropeptide dynamics with genetically encoded biosensors

Dong, C., Gowrishankar, R., Jin, Y., He, X. J., Gupta, A., Wang, H., Sayar-Atasoy, N., Flores, R. J., Mahe, K., Tjahjono, N., Liang, R., Marley, A., Or Mizuno, G., Lo, D. K., Sun, Q., Whistler, J. L., Li, B., Gomes, I., Von Zastrow, M., … Tian, L. (2024). Unlocking opioid neuropeptide dynamics with genetically encoded biosensors. Nature Neuroscience, 1–14.
 

Conditioned overconsumption is dependent on reinforcer type in lean, but not obese, mice

Lewis-Sanders, D., Bullich, S., Olvera, M.-J., Vo, J., Hwang, Y.-S., Mizrachi, E., & Stern, S. A. (2024). Conditioned overconsumption is dependent on reinforcer type in lean, but not obese, mice. Appetite, 198, 107355.
 

Applications of functional neurotransmitter release imaging with genetically encoded sensors in psychiatric research.

Wright, E. C., Scott, E., & Tian, L. (2024). Applications of functional neurotransmitter release imaging with genetically encoded sensors in psychiatric research. Neuropsychopharmacology, 1–5.
 

Prefrontal cortical dynorphin peptidergic transmission constrains threat-driven behavioral and network states

Wang, H., Flores, R. J., Yarur, H. E., Limoges, A., Bravo-Rivera, H., Casello, S. M., Loomba, N., Enriquez-Traba, J., Arenivar, M., Wang, Q., Ganley, R., Ramakrishnan, C., Fenno, L. E., Kim, Y., Deisseroth, K., Or, G., Dong, C., Hoon, M. A., Tian, L., & Tejeda, H. A. (2024). Prefrontal cortical dynorphin peptidergic transmission constrains threat-driven behavioral and network states. Neuron, 112(12), 2062-2078.e7.
 

Astrocyte coverage of excitatory synapses correlates to measures of synapse structure and function in ferret primary visual cortex

Thomas, C. I., Ryan, M. A., McNabb, M. C., Kamasawa, N., & Scholl, B. (2024). Astrocyte coverage of excitatory synapses correlates to measures of synapse structure and function in ferret primary visual cortex. Glia. 

Cannabinoids regulate an insula circuit controlling water intake

Zhao, Z., Covelo, A., Couderc, Y., Mitra, A., Varilh, M., Wu, Y., Jacky, D., Fayad, R., Cannich, A., Bellocchio, L., Marsicano, G., & Beyeler, A. (2024). Cannabinoids regulate an insula circuit controlling water intake. Current Biology, 0(0).
 

Phasic locus coeruleus activity enhances trace fear conditioning by increasing dopamine release in the hippocampus.

Wilmot, J. H., Diniz, C. R. A. F., Crestani, A. P., Puhger, K., Roshgadol, J., Tian, L., & Wiltgen, B. J. (2024). Phasic locus coeruleus activity enhances trace fear conditioning by increasing dopamine release in the hippocampus elife 12: RP91465
 

Synaptically-targeted long non-coding RNA SLAMR promotes structural plasticity by increasing translation and CaMKII activity

Espadas, I., Wingfield, J. L., Nakahata, Y., Chanda, K., Grinman, E., Ghosh, I., Bauer, K. E., Raveendra, B., Kiebler, M. A., Yasuda, R., Rangaraju, V., & Puthanveettil, S. (2024). Synaptically-targeted long non-coding RNA SLAMR promotes structural plasticity by increasing translation and CaMKII activity. Nature Communications, 15(1), 1–24.
 

5-HT_FAsTR: A versatile, label-free, high-throughput, fluorescence-based microplate assay to quantify serotonin transport and release

Bukowski, L., Strøm, M. E., Andersen, J. L., Maesen, J. B., Tian, L., & Sinning, S. (2024). 5-HT_FAsTR: A versatile, label-free, high-throughput, fluorescence-based microplate assay to quantify serotonin transport and release. Scientific Reports, 14(1), 6541.
 

INGEsT: An Open-Source Behavioral Setup for Studying Self-motivated Ingestive Behavior and Learned Operant Behavior

Zhao, Z., Xu, B., Loomis, C. L., Anthony, S. A., McKie, I., Srigiriraju, A., Bolton, M., & Stern, S. A. (2024). INGEsT: An Open-Source Behavioral Setup for Studying Self-motivated Ingestive Behavior and Learned Operant Behavior (p. 2024.03.10.584229). bioRxiv.  

NMNAT2 supports vesicular glycolysis via NAD homeostasis to fuel fast axonal transport.

Yang, S., Niou, Z.-X., Enriquez, A., LaMar, J., Huang, J.-Y., Ling, K., Jafar-Nejad, P., Gilley, J., Coleman, M. P., Tennessen, J. M., Rangaraju, V., & Lu, H.-C. (2024). NMNAT2 supports vesicular glycolysis via NAD homeostasis to fuel fast axonal transport. Molecular Neurodegeneration, 19(1), 13.
 

Targeted micro-fiber arrays for measuring and manipulating localized multi-scale neural dynamics over large, deep brain volumes during behavior

Vu, M.-A. T., Brown, E. H., Wen, M. J., Noggle, C. A., Zhang, Z., Monk, K. J., Bouabid, S., Mroz, L., Graham, B. M., Zhuo, Y., Li, Y., Otchy, T. M., Tian, L., Davison, I. G., Boas, D. A., & Howe, M. W. (2024). Targeted micro-fiber arrays for measuring and manipulating localized multi-scale neural dynamics over large, deep brain volumes during behavior. Neuron, 112(6), 909-923.e9.
 

VAP spatially stabilizes dendritic mitochondria to locally support synaptic plasticity.

Bapat, O., Purimetla, T., Kruessel, S., Shah, M., Fan, R., Thum, C., Rupprecht, F., Langer, J. D., & Rangaraju, V. (2024). VAP spatially stabilizes dendritic mitochondria to locally support synaptic plasticity. Nature Communications, 15: 205
 

Mapping of neuronal and glial primary cilia contactome and connectome in the human cerebral cortex.

Wu, J. Y., Cho, S.-J., Descant, K., Li, P. H., Shapson-Coe, A., Januszewski, M., Berger, D. R., Meyer, C., Casingal, C., Huda, A., Liu, J., Ghashghaei, T., Brenman, M., Jiang, M., Scarborough, J., Pope, A., Jain, V., Stein, J. L., Guo, J., … Anton, E. S. (2024). Mapping of neuronal and glial primary cilia contactome and connectome in the human cerebral cortex. Neuron, 112(1), 41-55.e3. https://doi.org/10.1016/j.neuron.2023.09.032
 

The Cousa objective: A long-working distance air objective for multiphoton imaging in vivo.

Yu, C.-H., Yu, Y., Adsit, L. M., Chang, J. T., Barchini, J., Moberly, A. H., Benisty, H., Kim, J., Young, B. K., Heng, K., Farinella, D. M., Leikvoll, A., Pavan, R., Vistein, R., Nanfito, B. R., Hildebrand, D. G. C., Otero-Coronel, S., Vaziri, A., Goldberg, J. L., … Smith, S. L. (2024). The Cousa objective: A long-working distance air objective for multiphoton imaging in vivo. Nature Methods, 21(1), 132–141.
 

Postsynaptic mitochondria are positioned to support functional diversity of dendritic spines.

Thomas, C. I., Ryan, M. A., Kamasawa, N., & Scholl, B. (2023). Postsynaptic mitochondria are positioned to support functional diversity of dendritic spines. eLife, 12, RP89682.
 

Meta-reinforcement learning via orbitofrontal cortex.

Hattori, R., Hedrick, N. G., Jain, A., Chen, S., You, H., Hattori, M., Choi, J.-H., Lim, B. K., Yasuda, R., & Komiyama, T. (2023). Meta-reinforcement learning via orbitofrontal cortex. Nature Neuroscience.
 

Screening Morphological Characteristics of Large Populations of Synaptic Vesicle Clouds and Active Zones from 3D EM Data

Thomas, C. I., Anderson, J. R., Bolton, M., & Kamasawa, N. (2023). Screening Morphological Characteristics of Large Populations of Synaptic Vesicle Clouds and Active Zones from 3D EM Data. Microscopy and Microanalysis: The Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada, 29(29 Suppl 1), 1084–1085.  

Feed-forward metabotropic signaling by Cav1 Ca2+ channels supports pacemaking in pedunculopontine cholinergic neurons.

Tubert, C., Zampese, E., Pancani, T., Tkatch, T., & Surmeier, D. J. (2023). Feed-forward metabotropic signaling by Cav1 Ca2+ channels supports pacemaking in pedunculopontine cholinergic neurons. Neurobiology of Disease, 188, 106328.
 

Sexual differentiation of neural mechanisms of stress sensitivity during puberty.

Wright, E. C., Luo, P. X., Zakharenkov, H. C., Serna Godoy, A., Lake, A. A., Prince, Z. D., Sekar, S., Culkin, H. I., Ramirez, A. V., Dwyer, T., Kapoor, A., Corbett, C., Tian, L., Fox, A. S., & Trainor, B. C. (2023). Sexual differentiation of neural mechanisms of stress sensitivity during puberty. Proceedings of the National Academy of Sciences of the United States of America, 120(43), e2306475120.
 

Social memory deficit caused by dysregulation of the cerebellar vermis.

Chao, O. Y., Pathak, S. S., Zhang, H., Augustine, G. J., Christie, J. M., Kikuchi, C., Taniguchi, H., & Yang, Y.-M. (2023). Social memory deficit caused by dysregulation of the cerebellar vermis. Nature Communications, 14(1), 6007.
 

Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors.

Vargas, M. V., Dunlap, L. E., Dong, C., Carter, S. J., Tombari, R. J., Jami, S. A., Cameron, L. P., Patel, S. D., Hennessey, J. J., Saeger, H. N., McCorvy, J. D., Gray, J. A., Tian, L., & Olson, D. E. (2023). Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors. Science, 379(6633), 700–706. https://doi.org/10.1126/science.adf0435
 

Cell-type-specific plasticity shapes neocortical dynamics for motor learning.

Shouvik Majumder, Koichi Hirokawa, Zidan Yang, Charles R. Gerfen, Lorenzo Fontolan, Sandro Romani, Anant Jain, Ryohei Yasuda, & Hidehiko K. Inagaki. (2023). Cell-type-specific plasticity shapes neocortical dynamics for motor learning. BioRxiv, 2023.08.09.552699.
 

Local autocrine plasticity signaling in single dendritic spines by insulin-like growth factors.

Tu, X., Jain, A., Parra Bueno, P., Decker, H., Liu, X., & Yasuda, R. (2023). Local autocrine plasticity signaling in single dendritic spines by insulin-like growth factors. Science Advances, 9(31), eadg0666.
 

An adaptive behavioral control motif mediated by cortical axo-axonic inhibition.

Jung, K., Chang, M., Steinecke, A., Burke, B., Choi, Y., Oisi, Y., Fitzpatrick, D., Taniguchi, H., & Kwon, H.-B. (2023). An adaptive behavioral control motif mediated by cortical axo-axonic inhibition. Nature Neuroscience.
 

Lighting up action potentials with fast and bright voltage sensors.

Andreoni, A., & Tian, L. (2023). Lighting up action potentials with fast and bright voltage sensors. Nature Methods, 20(7), Article 7. https://doi.org/10.1038/s41592-023-01928-6 

Dual regulation of spine-specific and synapse-to-nucleus signaling by PKCδ during plasticity.

Colgan, L. A., Parra-Bueno P., Holman, H. L., Tu, X., Jain, A., Calubag, M. F., Misler, J. A., Gary, C., Oz, G., Suponitsky-Kroyter, I., Okaz, E., & Yasuda, R. (2023). Dual regulation of spine-specific and synapse-to-nucleus signaling by PKCδ during plasticity. The Journal of Neuroscience, 43 (30) 5432-5447. 

Behavioral and Transcriptome Profiling of Heterozygous Rab10 Knock-Out Mice.

Bunner, W., Wang, J., Cohen, S., Bashtovyy, D., Perry, R., Shookster, D., Landry, T., Harris, E. M., Stackman, R., Tran, T. D., Yasuda, R., & Szatmari, E. M. (2023). Behavioral and Transcriptome Profiling of Heterozygous Rab10 Knock-Out Mice. ENeuro, 10(5), ENEURO.0459-22.2023.
 

Behavioral encoding across timescales by region-specific dopamine dynamics.

Jørgensen SH, Ejdrup AL, Lycas MD, Posselt LP, Madsen KL, Tian L, Dreyer JK, Herborg F, Sørensen AT, Gether U. Behavioral encoding across timescales by region-specific dopamine dynamics. Proc Natl Acad Sci U S A. 2023 Feb 14;120(7):e2215230120.  

Expression of a Form of Cerebellar Motor Memory Requires Learned Alterations to the Activity of Inhibitory Molecular Layer Interneurons.

Bonnan, A., Zhang, K., Gaffield, M. A., & Christie, J. M. (2023). Expression of a Form of Cerebellar Motor Memory Requires Learned Alterations to the Activity of Inhibitory Molecular Layer Interneurons. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 43(4), 601–612.  

Amygdala Intercalated Cells: Gate Keepers and Conveyors of Internal State to the Circuits of Emotion.

Asede, D., Doddapaneni, D., & Bolton, M. M. (2022). Amygdala Intercalated Cells: Gate Keepers and Conveyors of Internal State to the Circuits of Emotion. Journal of Neuroscience, 42(49), 9098–9109.
 

Fluorescence Screens for Identifying Central Nervous System–Acting Drug–Biosensor Pairs for Subcellular and Supracellular Pharmacokinetics.

Beatty, Z. G., Muthusamy, A. K., Unger, E. K., Dougherty, D. A., Tian, L., Looger, L. L., Shivange, A. V., Bera, K., Lester, H. A., & Nichols, A. L. (2022). Fluorescence Screens for Identifying Central Nervous System–Acting Drug–Biosensor Pairs for Subcellular and Supracellular Pharmacokinetics. Bio-Protocol, 12(22), e4551.

 

Presynaptic Rac1 controls synaptic strength through the regulation of synaptic vesicle priming.

Keine, C., Al-Yaari, M., Radulovic, T., Thomas, C. I., Valino Ramos, P., Guerrero-Given, D., Ranjan, M., Taschenberger, H., Kamasawa, N., & Young, S. M., Jr. (2022). Presynaptic Rac1 controls synaptic strength through the regulation of synaptic vesicle priming. ELife, 11, e81505.
 

Post-developmental plasticity of the primary rod pathway allows restoration of visually guided behaviors.

Cao, Y., Fajardo, D., Guerrero-Given, D., Samuel, M. A., Ohtsuka, T., Boye, S. E., Kamasawa, N., & Martemyanov, K. A. (2022). Post-developmental plasticity of the primary rod pathway allows restoration of visually guided behaviors. Current Biology, 0(0).
 

CaMKII: A central molecular organizer of synaptic plasticity, learning and memory.

Yasuda, R., Hayashi, Y., & Hell, J. W. (2022). CaMKII: A central molecular organizer of synaptic plasticity, learning and memory. Nature Reviews. Neuroscience.
 

Roundup and glyphosate’s impact on GABA to elicit extended proconvulsant behavior in Caenorhabditis elegans.

Naraine, A. S., Aker, R., Sweeney, I., Kalvey, M., Surtel, A., Shanbhag, V., & Dawson-Scully, K. (2022). Roundup and glyphosate’s impact on GABA to elicit extended proconvulsant behavior in Caenorhabditis elegans. Scientific Reports, 12(1), 13655.
 

Development of visual response selectivity in cortical GABAergic interneurons.

Chang, J. T., & Fitzpatrick, D. (2022). Development of visual response selectivity in cortical GABAergic interneurons. Nature Communications, 13(1), 3791.
 

Selective enhancement of neural coding in V1 underlies fine-discrimination learning in tree shrew

Schumacher, J. W., McCann, M. K., Maximov, K. J., & Fitzpatrick, D. (2022). Selective enhancement of neural coding in V1 underlies fine-discrimination learning in tree shrew. Current Biology, 32, 1-16.
 

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