Cortical inhibitory interneurons (INs) play a critical role in shaping and balancing neuronal activity and thus have been implicated in brain disorders such as epilepsy, autism, and schizophrenia. They display diverse subtypes, which differ in morphology, physiology, and connectivity. Such cell type diversity is thought to be essential for various types of circuit operations. Therefore, elucidating development, connectivity, and function of IN subtypes is crucial to understanding principles of the brain construction and function in normal and disease brains. To address these questions, we employ mouse genetics, molecular biology, virology, and imaging techniques.
INs display diverse subtypes, which innervate distinct compartments (e.g., dendrites, somata, and axon initial segments) of excitatory principal neurons (PNs) and regulate various types of circuit operations. There are many outstanding questions about the cell type specification, assembly, organization, and structural plasticity of cortical INs. To address these questions, we employ mouse genetics, molecular/cellular biology, virology, and imaging techniques.