Recent Papers
Development of coherent cortical responses reflects increased discriminability of feedforward inputs and their alignment with recurrent circuits.
Lempel, A. A., Trägenap, S., Tepohl, C., Kaschube, M., & Fitzpatrick, D. (2025). Development of coherent cortical responses reflects increased discriminability of feedforward inputs and their alignment with recurrent circuits. Neuron, 113(22), 3834-3845.e8.
The developmental emergence of reliable cortical representations
Trägenap, S., Whitney, D. E., Fitzpatrick, D., & Kaschube, M. (2025). The developmental emergence of reliable cortical representations. Nature Neuroscience, 1–12.
Eye saccades align optic flow with retinal specializations during object pursuit in freely moving ferrets.
Wallace, D. J., Voit, K.-M., Machado, D. M., Bahadorian, M., Sawinski, J., Greenberg, D. S., Stahr, P., Holmgren, C. D., Bassetto, G., Rosselli, F. B., Koseska, A., Fitzpatrick, D., & Kerr, J. N. D. (2025). Eye saccades align optic flow with retinal specializations during object pursuit in freely moving ferrets. Current Biology, 0(0).
The Cousa objective: A long-working distance air objective for multiphoton imaging in vivo.
Yu, C.-H., Yu, Y., Adsit, L. M., Chang, J. T., Barchini, J., Moberly, A. H., Benisty, H., Kim, J., Young, B. K., Heng, K., Farinella, D. M., Leikvoll, A., Pavan, R., Vistein, R., Nanfito, B. R., Hildebrand, D. G. C., Otero-Coronel, S., Vaziri, A., Goldberg, J. L., … Smith, S. L. (2024). The Cousa objective: A long-working distance air objective for multiphoton imaging in vivo. Nature Methods, 21(1), 132–141.
An adaptive behavioral control motif mediated by cortical axo-axonic inhibition.
Jung, K., Chang, M., Steinecke, A., Burke, B., Choi, Y., Oisi, Y., Fitzpatrick, D., Taniguchi, H., & Kwon, H.-B. (2023). An adaptive behavioral control motif mediated by cortical axo-axonic inhibition. Nature Neuroscience.
Development of visual response selectivity in cortical GABAergic interneurons.
Chang, J. T., & Fitzpatrick, D. (2022). Development of visual response selectivity in cortical GABAergic interneurons. Nature Communications, 13(1), 3791.
Selective enhancement of neural coding in V1 underlies fine-discrimination learning in tree shrew
Schumacher, J. W., McCann, M. K., Maximov, K. J., & Fitzpatrick, D. (2022). Selective enhancement of neural coding in V1 underlies fine-discrimination learning in tree shrew. Current Biology, 32, 1-16.
What and Where: Location-Dependent Feature Sensitivity as a Canonical Organizing Principle of the Visual System.
Sedigh-Sarvestani, M., & Fitzpatrick, D. (2022). What and Where: Location-Dependent Feature Sensitivity as a Canonical Organizing Principle of the Visual System. Frontiers in Neural Circuits, 16.
A binocular synaptic network supports interocular response alignment in visual cortical neurons
Scholl, B.*, Tepohl, C.*, Ryan, M. A., Thomas, C., Kamasawa, N., & Fitzpatrick, D. (2022). A binocular synaptic network supports interocular response alignment in visual cortical neurons. Neuron, 110, 1–12.
A sinusoidal transformation of the visual field is the basis for periodic maps in area V2
Sedigh-Sarvestani, M., Lee, K-S., Jaepel, J., Satterfield, R., Shultz, N., Fitzpatrick, D. (2021). A sinusoidal transformation of the visual field is the basis for periodic maps in area V2. Neuron Volume 109, Issue 24, 15 December 2021, Pages 4068-4079.e6
Cortical response selectivity derives from strength in numbers of synapses
Benjamin Scholl*, Connon I. Thomas*, Melissa A. Ryan, Naomi Kamasawa, David Fitzpatrick (2021). Cortical response selectivity derives from strength in numbers of synapses. Nature 590: 111-114
Targeting Functionally Characterized Synaptic Architecture Using Inherent Fiducials and 3D Correlative Microscopy.
Thomas, C.I., Ryan, M.A., Scholl, B., Guerrero-Given, D., Fitzpatrick, D., and Kamasawa, N. (2020). Targeting Functionally Characterized Synaptic Architecture Using Inherent Fiducials and 3D Correlative Microscopy. Microscopy and Microanalysis 1–14.
Interplay between cell-adhesion molecules governs synaptic wiring of cone photoreceptors
Cao, Y., Wang, Y., Dunn, H.A., Orlandi, C., Shultz, N., Kamasawa, N., Fitzpatrick, D., Li, W., Zeitz, C., Hauswirth, W., et al. (2020). Interplay between cell-adhesion molecules governs synaptic wiring of cone photoreceptors. PNAS. 117, 38, 23914-23924.
Experience-Dependent Reorganization Drives Development of a Binocularly Unified Cortical Representation of Orientation
Chang, J.T., Whitney, D., and Fitzpatrick, D. (2020). Experience-Dependent Reorganization Drives Development of a Binocularly Unified Cortical Representation of Orientation. Neuron, 107: 338-350.e5
Cortical synaptic architecture supports flexible sensory computations. Current Opinion in Neurobiology.
Scholl, B., and Fitzpatrick, D. (2020). Cortical synaptic architecture supports flexible sensory computations. Current Opinion in Neurobiology 64, 41–45.
Functional Logic of Layer 2/3 Inhibitory Connectivity in the Ferret Visual Cortex.
Scholl, B., Wilson, D.E., Jaepel, J., and Fitzpatrick, D. (2019). Functional Logic of Layer 2/3 Inhibitory Connectivity in the Ferret Visual Cortex. Neuron 104, 451-457.e3..
Functional Synaptic Architecture of Callosal Inputs in Mouse Primary Visual Cortex
Lee, K.-S., Vandemark, K., Mezey, D., Shultz, N., and Fitzpatrick, D. (2019). Functional Synaptic Architecture of Callosal Inputs in Mouse Primary Visual Cortex. Neuron 101, 421-428.E5.
Distributed network interactions and their emergence in developing neocortex
Smith, G.B., Hein, B., Whitney, D.E., Fitzpatrick, D., and Kaschube, M. (2018). Distributed network interactions and their emergence in developing neocortex. Nature Neuroscience 21, 1600-1608.
Differential tuning of excitation and inhibition shapes direction selectivity in ferret visual cortex.
Wilson, D.E.*, Scholl, B.*, and Fitzpatrick, D. (2018). Differential tuning of excitation and inhibition shapes direction selectivity in ferret visual cortex. Nature 560, 97–101.
Local Order within Global Disorder: Synaptic Architecture of Visual Space.
Scholl, B., Wilson, D.E., and Fitzpatrick, D. (2017). Local Order within Global Disorder: Synaptic Architecture of Visual Space. Neuron 96, 1127-1138.
GABAergic Neurons in Ferret Visual Cortex Participate in Functionally Specific Networks.
Wilson, D.E., Smith, G.B., Jacob, A.L., Walker, T., Dimidschstein, J., Fishell, G., and Fitzpatrick, D. (2017). GABAergic Neurons in Ferret Visual Cortex Participate in Functionally Specific Networks. Neuron 93, 1058–1065.
Video-rate volumetric functional imaging of the brain at synaptic resolution.
Lu, R., Sun, W., Liang, Y., Kerlin, A., Bierfeld, J., Seelig, J.D., Wilson, D.E., Scholl, B., Mohar, B., Tanimoto, M., Koyama, M., Fitzpatrick, D., Orger, M.B., Ji, N. (2017). Video-rate volumetric functional imaging of the brain at synaptic resolution. Nat. Neurosci. 20, 620–628.
A viral strategy for targeting and manipulating interneurons across vertebrate species.
Dimidschstein, J., Chen, Q., Tremblay, R., Rogers, S.L., Saldi, G.-A., Guo, L., Xu, Q., Liu, R., Lu, C., Chu, J., et al. (2016). A viral strategy for targeting and manipulating interneurons across vertebrate species. Nat Neurosci 19, 1743–1749.
Viral Injection and Cranial Window Implantation for In Vivo Two-Photon Imaging.
Smith, G.B., and Fitzpatrick, D. (2016). Viral Injection and Cranial Window Implantation for In Vivo Two-Photon Imaging. Methods Mol. Biol. 1474, 171–185.
Orientation selectivity and the functional clustering of synaptic inputs in primary visual cortex.
Wilson, D.E., Whitney, D.E., Scholl, B., and Fitzpatrick, D. (2016). Orientation selectivity and the functional clustering of synaptic inputs in primary visual cortex. Nat Neurosci . 19, 1003-1009.
Topology of ON and OFF inputs in visual cortex enables an invariant columnar architecture
Lee, K-S., Huang, X., Fitzpatrick, D. (2016). Topology of ON and OFF inputs in visual cortex enables an invariant columnar architecture. Nature. 533, 90–94.
Primate Thalamus: More Than Meets an Eye
Wallace, D.J., Fitzpatrick, D., and Kerr, J.N.D. (2016). Primate Thalamus: More Than Meets an Eye. Curr. Biol. 26, R60–R61.
Modular Representation of Luminance Polarity in the Superficial Layers of Primary Visual Cortex.
Smith, G.B., Whitney, D.E., and Fitzpatrick, D. (2015b). Modular Representation of Luminance Polarity in the Superficial Layers of Primary Visual Cortex. Neuron 88, 805–818.
ON and OFF subfield organization of layer 2/3 neurons in tree shrew visual cortex.
Lee, K.-S., Huang, X., and Fitzpatrick, D. (2015). ON and OFF subfield organization of layer 2/3 neurons in tree shrew visual cortex. J Vis 15, 990–990.
The development of cortical circuits for motion discrimination.
Smith, G.B., Sederberg, A., Elyada, Y.M., Van Hooser, S.D., Kaschube, M., and Fitzpatrick, D. (2015a). The development of cortical circuits for motion discrimination. Nat. Neurosci. 18, 252–261.
Optogenetic assessment of horizontal interactions in primary visual cortex.
Huang, X., Elyada, Y.M., Bosking, W.H., Walker, T., and Fitzpatrick, D. (2014). Optogenetic assessment of horizontal interactions in primary visual cortex. J. Neurosci. 34, 4976–4990.
Neural maps.
Fitzpatrick, D., and Ulanovsky, N. (2014). Editorial overview: Neural maps. Current Opinion in Neurobiology 24, iv – vi.
Transformation of receptive field properties from lateral geniculate nucleus to superficial V1 in the tree shrew.
Van Hooser, S.D., Roy, A., Rhodes, H.J., Culp, J.H., and Fitzpatrick, D. (2013). Transformation of receptive field properties from lateral geniculate nucleus to superficial V1 in the tree shrew. J Neurosci 33, 11494–11505.
Specifying cortical circuits: a role for cell lineage.
Smith, G.B., and Fitzpatrick, D. (2012). Specifying cortical circuits: a role for cell lineage. Neuron 75, 4–5.
Initial neighborhood biases and the quality of motion stimulation jointly influence the rapid emergence of direction preference in visual cortex.
Van Hooser, S.D., Li, Y., Christensson, M., Smith, G.B., White, L.E., and Fitzpatrick, D. (2012). Initial neighborhood biases and the quality of motion stimulation jointly influence the rapid emergence of direction preference in visual cortex. The Journal of Neuroscience : The Official Journal of the Society for Neuroscience 32, 7258–7266.
Dynamics of population response to changes of motion direction in primary visual cortex.
Wu, W., Tiesinga, P.H., Tucker, T.R., Mitroff, S.R., and Fitzpatrick, D. (2011). Dynamics of population response to changes of motion direction in primary visual cortex. The Journal of Neuroscience : The Official Journal of the Society for Neuroscience 31, 12767–12777.
The Representation of S-Cone Signals in Primary Visual Cortex.
Johnson, E.N., Hooser, S.D.V., and Fitzpatrick, D. (2010). The Representation of S-Cone Signals in Primary Visual Cortex. J. Neurosci. 30, 10337–10350.
A precise form of divisive suppression supports population coding in the primary visual cortex.
MacEvoy, S.P., Tucker, T.R., and Fitzpatrick, D. (2009). A precise form of divisive suppression supports population coding in the primary visual cortex. Nat. Neurosci. 12, 637–645.
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