Research

Understanding the functional organization of the nervous system, its capacity to produce perception, thought, language, memory, emotion, and action, remains the ultimate challenge for biology. Meeting this challenge requires forging links between different levels of analysis — genetic, molecular, cellular, circuit, and behavioral — and developing new technologies that make cutting edge scientific discoveries possible.

Each of the seven Labs at MPFI focuses on one research area

Disorders of neural circuit function

Research in the Bolton Lab employs electrophysiological and imaging techniques to study alterations in circuit structure and function in mouse models of neurological and psychiatric disorders.

to Bolton Lab

Mechanisms of synaptic signaling and computation

The Christie Lab seeks to understand how the dynamics of information transfer and transformation within and between neurons is utilized by the cerebellum to control movement and encode a memory of motor learning.

to Christie Lab

Functional architecture and development of cerebral cortex

Research in the Fitzpatrick Lab utilizes state-of-the-art in vivo imaging techniques to probe the functional synaptic architecture of circuits in primary visual cortex.

to Fitzpatrick Lab

Neural dynamics and cognitive functions

The main goal of Inagaki lab is to develop a cellular and network-level understanding of how internal states, such as internal drives and urgency, modify dynamics in the frontal cortex to influence cognitive functions.

to Inagaki Lab

Development and function of inhibitory neural circuits

Research in the Taniguchi Lab uses advanced imaging techniques and genetic approaches to uncover the axonal and synaptic development and physiological function of chandelier cells.

to Taniguchi Lab

Neuronal mechanisms of episodic memory

The Wang Lab integrates electrophysiological, imaging, and optogenetic approaches with computational modeling to reveal the circuit underpinnings of the sequential neuronal activity underlying our ability to remember, think, and plan.

to Wang Lab

Neuronal signal transduction

The Yasuda Lab is interested in the operation principles of signaling networks in dendritic spines. They have been developing techniques to image activity of various proteins in single dendritic spines using 2pFLIM in combination with new biosensors.

to Yasuda Lab

Support the research at MPFI