Understanding the functional organization of the nervous system, its capacity to produce perception, thought, language, memory, emotion, and action, remains the ultimate challenge for biology. Meeting this challenge requires forging links between different levels of analysis — genetic, molecular, cellular, circuit, and behavioral — and developing new technologies that make cutting edge scientific discoveries possible.

Each of the seven Labs at MPFI focuses on one research area

Disorders of neural circuit function

Research in the Bolton Lab employs electrophysiological and imaging techniques to study alterations in circuit structure and function in mouse models of neurological and psychiatric disorders.

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Mechanisms of synaptic signaling and computation

The Christie Lab seeks to understand how the dynamics of information transfer and transformation within and between neurons is utilized by the cerebellum to control movement and encode a memory of motor learning.

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Functional architecture and development of cerebral cortex

Research in the Fitzpatrick Lab utilizes state-of-the-art in vivo imaging techniques to probe the functional synaptic architecture of circuits in primary visual cortex.

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Neural dynamics and cognitive functions

The main goal of Inagaki lab is to develop a cellular and network-level understanding of how internal states, such as internal drives and urgency, modify dynamics in the frontal cortex to influence cognitive functions.

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Development and function of inhibitory neural circuits

Research in the Taniguchi Lab uses advanced imaging techniques and genetic approaches to uncover the axonal and synaptic development and physiological function of chandelier cells.

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Neuronal mechanisms of episodic memory

The Wang Lab integrates electrophysiological, imaging, and optogenetic approaches with computational modeling to reveal the circuit underpinnings of the sequential neuronal activity underlying our ability to remember, think, and plan.

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Neuronal signal transduction

The Yasuda Lab is interested in the operation principles of signaling networks in dendritic spines. They have been developing techniques to image activity of various proteins in single dendritic spines using 2pFLIM in combination with new biosensors.

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The Rangaraju Lab is interest in dissecting mitochondrial function and its optimization in neuronal compartments. They focus on the proteins that comprise and regulate mitochondria and the other energy supplies such as glycolysis and glial-neuronal networks in different neuronal compartments.

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Integrative Neural Circuits and Behavior

The Stern Lab studies how learning mechanisms and diverse environmental stimuli alter innate brain circuits to drive both adaptive and maladaptive behavioral outcomes.

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