Seminar
The neuronal gene Arc is essential for long-lasting information storage in the mammalian brain, mediates various forms of synaptic plasticity, and has been implicated in neurodevelopmental disorders. However,…
We have examined the microcircuit mechanisms of place field generation using whole-cell voltage recordings and two-photon optical imaging of hippocampal CA1 neurons in mice running on a linear…
We trigger actions in response to external sensory cues, like pushing the gas pedal when the lights turn green. This cue-triggered action is often spared in Parkinson’s patients,…
Fluid homeostasis is a vital function that regulates the balance between water and sodium. When this balance shifts in one direction, the brain detects the changes and triggers…
The thalamus and cerebral cortex are intimately interconnected by a dense network of feedforward and feedback circuits. In the visual system, the response properties of neurons in the…
In active avoidance tasks, subjects have to learn to execute particular actions in order to avoid an aversive stimulus, such as a shock. Such paradigms pose a number…
The remarkable cognitive abilities characterizing humans has been linked to unique patterns of connectivity characterizing the neocortex. Comparative studies have shown that human cortical pyramidal neurons (PN) receive…
Henry Dunn Laboratory of Dr. Kirill Martemyanov, Scripps Research Endogenous trans-synaptic modulators of group III mGluRs temper neuropsychiatric manifestations Trans-synaptic modulation of GPCRs represents an emerging dimension in…
Like walking or speaking, most of our movements have predictable acoustic consequences. Our brain’s ability to recognize self-generated sounds such as these is critical for normal hearing as well as for learning…
Recent advances in computer vision have made accurate, fast and robust measurement of animal behavior a reality. In the past years powerful tools specifically designed to aid the…